Scientists in Prague, Czechoslovakia, latterly recognized the compound aeruginascin in Psilocybe cubensis magic mushrooms.1 In their paper denote in Drug Testing and Analysis, Klára Gotvaldová and her research group aforementioned: “ extraction approach and a UHPLC-MS/MS analytical approach for the evaluation of psilocybin, psilocin, baeocystin, norbaeocystin, and aeruginascin in flora biomass.” 

In step with the paper, some of those analytes have been present withinside the P. cubensis samples studied. The authors mentioned that “concentrations of aeruginascin are low and feature presently not been stated before.” This paper is that the number one report of the compound aeruginascin in any mushroom aside from Inocybe aeruginascens2 or Pholiotina cyanopus.3

Coming Up to Speed with Aeruginascin

Aeruginascin become first found with the aid of using Jochen Gartz in 1987 in Inocybe aeruginascens, a mushroom containing psilocybin.2 Gartz determined that this species had an excessively excessive hobby in what he hypothesized at the time could come to be aeruginascin. 

He made all of the different thrilling statements in a later 1989 article. four Gartz at the evaluation and analyzed 24-time critiques of individuals who with the assist of threat ingested I. aeruginascens to individuals who with the assist of threat ate buy magic mushrooms canada species with excessive tiers of psilocybin and psilocin.

People who ingested I. Aeruginascens handiest expressed euphoric criticism. Gartz defined the effects in folks that ingested mushrooms with excessive tiers of psilocybin and psilocin as a "frequently mild and occasionally profound dysphoric mood" decided thru psychosis, panic, and anxiety. Furthermore, Gartz determined on this take a look at that the tiers of aeruginascin in the mushrooms had been much like the ones of psilocybin and baeocystin.

In addition, as Robert Emmet Sherwood et al. reviewed in their 2020 paper, there exist anecdotal critiques of muscle paralysis, weakness, or every in people even as intake some of the species of psychedelic mushrooms containing aeruginascin. five Sherwood et al. state, “The speculations on the ones sports activities are for the maximum element unsubstantiated, tho' the belief is tempting given the structural similarity of aeruginascin to bufotenedine, a anuran noxious substance stated to be a remarkable peripherally lively five-HT3 agonist.” The authors added, “ the medical sphere interest of aeruginascin remains unexplored.”

The Impact of This New Study on Psychedelic Mushroom Research

New discoveries add to and exchange scientific theories all the time. Recall that the magic mushroom compound norpsilocin wasn’t discovered until 20177 and has due to the fact been established to have performance exceeding psilocin’s.5 This exam from Gotvaldová et al. highlights the importance of statistics at the chemical composition of magic mushrooms–collectively with all the active molecules, now not honestly psilocybin.

Their artwork display that aeruginascin is greater regular in mushrooms than scientists first of all thought. And its presence makes experience given scientists’ statistics of the biosynthetic pathway for making psilocybin and unique tryptamine compounds in mushrooms.

From a structural standpoint, aeruginascin is purely psilocin with one similarly alkyl (see instance above). Theoretically, every other methyl organization can be intercalary to psilocybin through the methyltransferase enzymes that mushrooms use to create psilocybin. eight From this perspective, it’s particularly stunning that aeruginascin isn’t present in extra species and forms of magic mushrooms. Unless it is, and it’s simply that no one has long past searching for it yet.

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