It's an NFL wild-cardweekendlike none other.The featuresix wild-card matchupsover a two-day stretch that should produce an overload ofexcitement for NFL fans.Indianapolis and Buffalo open the playoff bracketat 1:05 p.m.ETon Saturday. Los Angeles and Seattle Detroit Lions Sleepwear Underwear will meet for the third time in the 4:40 p.m. slot, which sets up a prime-time matchup between Tampa Bay and Washington at 8:15 p.m.Sunday's schedule featuresanother tripleheader. Baltimore and Tenne see meet in a rematch of last year's AFC divisional playoff game at 1:05 p.m. Chicago faces New Orleansat 4:40 p.m. Cleveland makes its first playoff appearances since 2003 against the rival Steelers at 8:15 p.m.Sporting News wrapped up the regular season with another solid week in our straight-up picks.We like the favorites this weekend, but we know anything can happen.Last Week: 13-3, .812 Regular season: 129-75, .632 With that in mind, below are our picks and predictions forWeek 17:MORE NFL PLAYOFFS: | | The referenced media source is mi sing and needs to be Tyrell Williams Jersey re-embedded.NFL playoff picks, predictions for 2021 wild-card gamesIndianapolis Colts at Buffalo Bills (-7) Saturday, 1:05 p.m., CBS The Bills covered the spread in eight straight games to close the season, part of a six-game winning streak that makes them one of the NFL's hottest teams.The Colts have a top-10 defense and Philip Rivers is an experience playoff quarterback, but they were 1-4 against the other AFC playoff teams this season.Buffalo wins its first playoff game since 1995 with another strong performance from Josh Allen.Pick: Bills 34, Colts 23Los Angeles Rams at Seattle Seahawks (-4.5) Saturday, 4:40 p.m., FOX If Jared Goff (thumb) can't go, then John Wolford will make his first career playoff start against the rival Seahawks.Seattle's offense has been hit-or-mi s with Ru sell Wilson the last few weeks, but the defense is allowing just 12.5 points per game through a four-game win streak.Wilson gets Seattle back in the NFC divisional round.It's hard to pick the Rams who have the league's top-scoring defense (18.5)if Goff cannot go.Pick: Seahawks 27, Rams 16MORE: Tampa Bay Buccaneers (-8)at Washington Football Team Saturday, 8:15 p.m., NBC Tampa Bay averaged 37ppg. in four straight victories to close theseason;a remarkable stretch under Tom Brady.Chase Young leads a John Penisini Jersey Washington defense that allows just 20.6 points per game, and it could get interesting if they stop the run. Alex Smith is a feel-good story in his first playoff start since career-threatening leg injury. The line has jumped 1.5points;a nod to the confidence in Brady and the Bucs.Pick:Buccaneers 28, Washington 21Baltimore Ravens (-3.5) at Tenne see Titans Saturday, Detroit Lions T Shirts 8:15 p.m., ESPNWe flip-flopped on this one for obvious reasons. The Titans beat the Ravens in last years playoff and won a 30-24 overtime thriller this season. Baltimore found its groove on offense after the 47-42 shootout against Cleveland, and Lamar Jackson was the difference. He finally wins his first playoff start in thrilling fashion.Pick: Ravens 36, Titans 31 The referenced media source is mi sing and needs to be re-embedded.Chicago Bears at New Orleans Saints (-9.5) Saturday, 4:40 p.m., CBS The Bears backed into the playoffs after losing to the Packers, and Mitchell Trubiskyis making hissecond playoff start. The Saints are optimistic Alvin Kamara will return from the COVID-19 list Joel Heath Jersey , and Drew Breesis coming off a three-TD performance in Week 17. New Orleans learns from last years wild-card lo s to Minnesota and returns to the divisional playoffs.Pick: Saints 31, Bears 21Cleveland Browns at Pittsburgh Steelers (-4) Saturday, 8:15 p.m., NBC The Browns beat the Steelers 26-24, and this is the first matchup between the teams since the 2003 AFC Wild Card thriller. Expect a similar game to break out. Clevelandleads at halftime behind a pair of Nick Chubb TDs.Baker Mayfield plays his best game to date at Heinz Field, much better than the last visit.The Steelers rally in the second half, however, and Ben Roethlisberger who is 24-2-1 against the Browns leads the way in the second half. Cleveland has a chance to tie late, but the Steelers come up with the stop this time.Pick: Steelers31,Browns 26