The Blood of the Ancients is one of the most powerful items in Diablo 2, as well as one of the most difficult to obtain in the game's world.Obtaining the Horadric Staff in Act II, the Horadric Cube in Act III, the Shaft and the Headpiece in Act IV, and the Horadric Cube in Act V is required to complete the quest. The Horadric Staff can be found in Acts II and III. Unlocking it is...