The and will wrap up the Thanksgiving slate to open up Week 12 when these club square off from Caesars Superdome. Week 11 was not kind to either of these teams as they both Tyler Naquin Jersey suffered lo ses and saw their opponent put up 40 or more points. This lo s was particularly impactful for Buffalo as they have now fallen out of first place in the AFC East, trailing the . Meanwhile, the Saints are back down to .500 on the season, but are still within the thick of the playoff picture in the NFC, clinging to the No. 7 seed in the conference.Below, we'll specifically be looking at the different betting angles that this primetime matchup has in store for us. We'll be taking a look at how the lines have moved throughout the week leading into Thursday night and, of course, give you our picks for this game along with a handful of our favorite player props.Date:Thursday, Nov. 25|Time:8:20 p.m. ETLocation:Caesars Superdome (New Orleans)TV: NBC|Stream:fuboTV ( )Follow:Odds:Bills -6, O/U 45.5 Latest Odds: New Orleans Saints +7 Brad Hand Jersey The Bills opened as a 4.5-point favorite and that number held even through the Week 11 slate. However, it has since bumped all the way to Bills -6, likely due to being ruled out along with a few other key Saints players due to injury. The pick: Bills -6.Buffalo is looking to rebound from that demoralizing home lo s to the and are set up nicely to do so in New Orleans. Not only is Kamara not suiting up, fellow running back is questionable and All-Pro right tackle Ryan Ramcyk has also been ruled out. Given that the Bills were just torn to shreds by to the tune of five touchdowns, avoiding an elite back like Kamara is much-needed. Buffalo has also averaged 6.3 yards per play over the last three weeks (second-best in the ), which could prose a problem for the Saints' defense that just allowed and the to post 40 points on Sunday and 380 yards of offenseKey trend: Bills are 3- Zach Duke Jersey 0-1 ATS following a straight-up lo s. The total for this prime-time affair opened at 48 but has fallen considerably as the week has progre sed. Coming out of Week 11, the total stood a 47, but as various Saints players are held out of this matchup, this number has fallen to 45.5.The pick: Under 45.5. If the Saints are going to be without this many key players, it's hard to imagine that will be able to put many points on the board, especially against this Buffalo defense that is still No. 1 in the NFL in DVOA entering Week 12. Even with the Bills averaging 31 points per game on the road this season, it's hard banking on the Saints to carry out their end of the bargain to have this go over. Key trend: Under is 8-0-1 in Saints last nine Thursday games. BUF QB #17 CMP%65.7YDs2811TD21INT8YD/Att7.36 Pa sing touchdowns:1.5 (Over -180, Under +150)Pa sing yards:276.5 (Over -115, Under -115)Total interceptions: 0.5 (Over -105, Under -125)Longest pa sing completion: 38.5 (Over -115, Under -115)Rushing yards: 32.5 Cleveland Guardians Jersey (Over -130, Under +100)The value isn't great at -180, but Allen has thrown multiple touchdowns in eight of his 10 games played this season, which points favorably to that prop going over on Thursday night. Allen's also gone over this rushing yards prop in six games this season. CHI QB #15 CMP%56.9YDs920TD8INT2YD/Att6.39 Pa sing yards:206.5 (Over -120, Under -110)Siemian has gone over this pa sing yards number in all three of his starts this seating leading into Week 12. That said, Buffalo is the No. 1 pa sing defense in DVOA this season. It's also worth noting that Siemian was listed on the injury report this week (as a full participant) with a right hand injury. total rushing yards: Over 24.5 (-115). Singletary is averaging nearly double this prop on the season and has gone over this total in eight of his 10games played this season. The Saints also just allowed two different backs (and Jalen Hurts) to rush for over 60 yards last week. total receptions: Over 3.5 (-110). Knox saw a season-high 10 targets last week against the Colts and brought in a season-high six receptions. While that increase Joe Carter Jersey in volume could be attributed to Buffalo trying to throw its way back into the blowout lo s against Indy, Knox does have a solid matchup again this week as the Saints are allowing 4.8 receptions per game this season to opposing tight ends and just allowed to catch five of his eight targets last week for 62 yards.