It's must-win time for several NFL teams believed to be playoff contenders coming into the year. The Texans and Vikings are both 0-3 and playing each other, and though Houston can point to a brutal opening schedule for its winle s record, it's hard to make excuses for this Minnesota team. The Falcons were a fringe playoff hopeful a few weeks ago and are "only" two meltdowns away from being 2-1, but if they lose again to the Packers on Monday, good night. And while the Eagles are just a half-game out of first place in the NFC (L)East, it sure feels like if they can't score an upset over the similarly-shorthanded 49ers, we can probably write them off. With two of the league's 3-0 teams forced to take an early bye due to , we're left with five others trying to maintain their undefeated record, including one in perhaps the biggest matchup of the week: Chiefs vs. Patriots. That is, if the game is even played after after players on both sides, including Cam Newton, also tested positive for COVID-19. Each week, we'll collect all of the best picks and gambling content from CBSSports.com and SportsLine in one place, so Max Scherzer Jersey you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. Enjoy our run-through of Week 4, and good luck in your games! All odds via William Hill Sportsbook. Time:Sunday, 1 p.m. ET (CBS), stream on Open:Buccaneers -7, O/U 45 Current:Buccaneers -7, O/U 42.5 Kenny White: " Tampa Bay's defense has come around because (Tom) Brady is there. Everybody in playing harder. They have so much enthusiasm -- they feel like they can win a Super Bowl, and that's the way they're playing. I can't back the Chargers in this spot, I'm going with the Bucs and I'm laying the points." R.J. White: "My best bet is the Under. The Chargers have been a strong Under team, even with this trend where everybody's going Over, all three of their games have been Under. They have an inconsistent offense and quality defense. I think Tampa's defense is better than its offense right now, so this looks like a strong Under play. Pete, tell me why Bobby Miller Jersey Kenny is wrong." Pete Prisco: "Well, I'm gonna take the seven. You're gonna give me seven with that Chargers defense and I'm gonna take it. You know what? Brady has been good when he's had everybody around, and he won't have everybody around again this week. So it's back to guys being hurt. ... I do think that (Justin) Herbert's played well. He's been able to do some things, and I think he'll show up here. So I'll take the points." That's from the Pick Six Podcast, where I join Pete Prisco, Kenny White and Will Brinson every Friday to break down all the games from a gambling perspective and give out best bets. Give it a listen below and in your feed daily. Pete Prisco Jason La Canfora Will Brinson Jared Dubin Ryan Wilson John Breech Dave Richard Jamey Eisenberg Chargers at Bucs (-7.5) Time:Sunday, 1 p.m. ET (FOX), stream on (Try for free) Open:Cowboys -5, O/U 56 Current:Cowboys -4.5, O/U 56 "I'm always inclined to take a look at the over when it comes to Cowboys home games. If we go back to AT&T Stadium opening for the 2009 season, the over has gone 52-40-1 overall for Cowboys home games. Since the start of the 2018 season, it's gone 12-6, including 1-0 this season. Through three weeks of the 2020 season, Cowboys games have featured an average of 61.7 points per game, and only the Vikings and Falcons (two teams that are both 0-3) have allowed more points than the 97 the Cowboys have given up this season. The Browns defense isn't much better. Cleveland might be Jackie Robinson Jersey 2-1, but it has a point differential of -13 after allowing 87 points in three games. This total feels too low." -- Tom Fornelli on why he took Over 55 in this game as one of his best bets Fornelli is coming off a strong 3-0 week with his best bets, and he's adding two spread picks to the Browns-Cowboys Over. You can in his Thursday column. Pete Prisco Jason La Canfora Will Brinson Jared Dubin Ryan Wilson John Breech Dave Richard Jamey Eisenberg Browns at Cowboys (-4.5) Time:Sunday, 1 p.m. ET (FOX), stream on (Try for free) Open:Cardinals -4, O/U 51 Current:Cardinals -3, O/U 51.5 "This line has moved well off the lookahead of Cardinals -5 based on the surprising results of last week, when the Cards lost as favorites and the Panthers won as underdogs. But the Cards were also Alex Wood Jersey -3 in turnover margin in their close lo s, while the Panthers were +4 in the same stat in their close win. Don't overreact! The Cardinals offense is consistently good (and should remain so even if DeAndre Hopkins sits), and the defense has played great situational football, ranking first in third-down percentage and second in red-zone percentage. I love the Cardinals to roll here unle s we have another wild turnover swing, which would surprise me." -- R.J. White on why the Cardinals are one of his five best spread bets for Week 4 I've cashed twice in the Las Vegas SuperContest, widely considered the toughest sports gambling competition in the world. I've also hit on over 57% of my picks over the past five years combined. You can against the SuperContest lines by heading to SportsLine, and use promo code WHITE to sign up for $1 for your first month of acce s to all SportsLine's picks and analysis. Pete Prisco Jason La Canfora Will Brinson Mark Lowe Jersey Jared Dubin Ryan Wilson John Breech Dave Richard Jamey Eisenberg Cardinals (-3.5) at Panthers Time:Sunday, 1 p.m. ET (FOX), stream on (Try for free) Open:Seahawks -7, O/U 54.5 Current:Seahawks -5.5, O/U 54 "The Dolphins registered a dominant, 31-13 win over the Jacksonville Jaguars last week, but I'm not sure if anyone watched that game and changed their minds on the Dolphins' potential in 2020. Miami can be solid, but Seattle is a legitimate contender led by a potential MVP. Last week, Ru sell Wilson became the fifth quarterback in history to throw five or more touchdown pa ses in consecutive games. He's the first quarterback with four or more touchdown pa ses in each of the first three games of a season and leads the NFL with a total of 14 pa sing touchdowns. Those are the most recorded by a quarterback in the first three games of a season in NFL history. In the r