Two young, exciting running backs square off on "Monday Night Football" as the host the at 8:15 p.m. ET. New York's is in the running for Rookie of the Year, while has been the one constant on a banged-up Niners offense. San Francisco opened as a 1.5-point favorite and now is laying a field goal. The over-under, which opened at 43.5, has ticked up to 45 in the latest 49ers vs. Giants odds. Before you make any 49ers vs. Giants picks and predictions, check out what Dk Metcalf Hoodies Sweatshirts the SportsLine Projection Model has to say. SportsLine's proprietary computer model went 176-80 last season and beat over 95 percent of CBS Office Pool players in 2016 and '17. It also performed better than 98 percent of experts tracked by NFLPickWatch.com during that span. Additionally, it went 48-34 on A-rated picks against the spread last season, and $100 bettors who followed it the past two seasons are up nearly $4,000. The model has continued to nail its top-rated picks in 2018, entering Week 10 on a strong 8-0 run. For the season, it is now 22-9 on all top-rated picks, extending its two-year run to a blistering 70-43. And when it comes to all straight-up picks, the model is 89-43 this season, again ranking in the top Marquise Blair Jersey 10 on NFLPickWatch.com Alex Collins Jersey . Anybody who has been following it is way, way up. Now, the model has simulated Giants vs. 49ers 10,000 times. We can tell you it's leaning over, projecting 49 points to be scored, but it also says there's plenty of value on one side of the spread. You can only get that pick at SportsLine. The model has factored in that the Niners' offense was running smoothly and efficiently in its 34-3 victory over the last time out. Undrafted quarterback played an incredible game, completing 16 of 22 pa ses for 262 yards and three touchdowns, and finishing with a nearly perfect quarterback rating of 151.9. Mullens had an instant rapport Jake Curhan Jersey with tight end , who broke off a 71-yard catch-and-run in the third quarter. That reception set up a 5-yard Mullens-to-Kittle score to put the game out of reach. Backup running back is out for the season with an arm injury, so expect plenty of carries from Breida. The second-year star, who has been dealing with an ankle injury, is averaging 5.5 yards per carry and has racked up an impre sive 531 rushing yards. But just because the 49ers looked like world-beaters in Week 9 doesn't mean they will crush the Giants. completion percentage is 68.3, almost a career high, and he has to sed just six interceptions. In his last game against the , he went 30 for 47 for 316 yards and a touchdown, leading a late rally that ultimately fell short. He will need a big game from three-time Pro Bowl wideout Jr. to lift the G-Men. No. 13 is among the league leaders in both receptions (61) and receiving yards (785). While the Giants' pa sing Steve Hutchinson T Shirts game is more than capable, Barkley makes this offense go. The alum is the ultimate dual threat, averaging 4.7 yards per carry while ama sing 1,016 yards from scrimmage with seven scores. So which side of the Giants vs. 49ers spread has all the value? , and find out.